Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: A 123I‐FP‐CIT SPECT study
Identifieur interne : 002055 ( Main/Exploration ); précédent : 002054; suivant : 002056Severity of neuropsychiatric symptoms and dopamine transporter levels in dementia with Lewy bodies: A 123I‐FP‐CIT SPECT study
Auteurs : Francesco Roselli [Italie, Allemagne] ; Nicola M. Pisciotta [Italie] ; Robert Perneczky [Allemagne] ; Michele Pennelli [Italie] ; Maria S. Aniello [Italie] ; Maria F. De Caro [Italie] ; Ermanno Ferrannini [Italie] ; Bruno Tartaglione [Italie] ; Giovanni Defazio [Italie] ; Giuseppe Rubini [Italie] ; Paolo Livrea [Italie]Source :
- Movement Disorders [ 0885-3185 ] ; 2009-10-30.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- 123I‐FP‐CIT SPECT, Aged, Caudate Nucleus (metabolism), Caudate Nucleus (radionuclide imaging), Delusion, Delusions (psychology), Delusions (radionuclide imaging), Dopamine, Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins (metabolism), Female, Hallucination, Hallucinations (psychology), Hallucinations (radionuclide imaging), Humans, Image Processing, Computer-Assisted, Lewy Body Disease (metabolism), Lewy Body Disease (psychology), Lewy Body Disease (radionuclide imaging), Lewy body dementia, Male, Middle Aged, Neostriatum (metabolism), Neostriatum (radionuclide imaging), Nervous system diseases, Neuropsychological Tests, Nucleus Accumbens (metabolism), Nucleus Accumbens (radionuclide imaging), Parkinson Disease (psychology), Parkinson Disease (radionuclide imaging), Parkinsonism, Photon, Psychiatric Status Rating Scales, Putamen (metabolism), Putamen (radionuclide imaging), Radiopharmaceuticals (diagnostic use), Single photon emission tomography, Tomography, Emission-Computed, Single-Photon, Tropanes (diagnostic use), delusion, dementia with Lewy bodies, hallucination, parkinsonism.
- MESH :
- chemical , diagnostic use : Radiopharmaceuticals, Tropanes.
- chemical , metabolism : Dopamine, Dopamine Plasma Membrane Transport Proteins.
- metabolism : Caudate Nucleus, Lewy Body Disease, Neostriatum, Nucleus Accumbens, Putamen.
- psychology : Delusions, Hallucinations, Lewy Body Disease, Parkinson Disease.
- radionuclide imaging : Caudate Nucleus, Delusions, Hallucinations, Lewy Body Disease, Neostriatum, Nucleus Accumbens, Parkinson Disease, Putamen.
- Aged, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Neuropsychological Tests, Psychiatric Status Rating Scales, Tomography, Emission-Computed, Single-Photon.
Abstract
Neuropsychiatric symptoms are frequent in dementia with Lewy bodies (DLB). Dopamine transporter (DAT) imaging with 123I‐labeled ligand N‐δ‐(fluoropropyl)‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)tropene (123I‐FP‐CIT), which reliably measures midbrain dopaminergic dysfunction, has provided important evidence on the neurobiological substrate of some of these symptoms including apathy and depression. However, little is known on DAT levels and other distressing symptoms such as delusions and hallucinations. Therefore, 123I‐FP‐CIT imaging was performed in 18 well‐characterized patients with DLB, and striatal DAT levels were correlated with the frequency/severity ratings of several neuropsychiatric symptoms. A wide range of neuropsychiatric symptoms could be observed in the sample. Significant correlations were observed between decreased striatal DAT levels and visual hallucinations. Although there were no correlations between striatal DAT levels and other neuropsychiatric symptoms, when considering the putamen and the caudate nucleus separately, delusions, depression, and apathy were inversely correlated to decreased caudate DAT levels. Theseresults provide intriguing evidence on the involvement of the mesocortical dopaminergic pathways in neuropsychiatric symptoms in DLB. © 2009 Movement Disorder Society
Url:
DOI: 10.1002/mds.22702
Affiliations:
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Le document en format XML
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>123I‐FP‐CIT SPECT</term>
<term>Aged</term>
<term>Caudate Nucleus (metabolism)</term>
<term>Caudate Nucleus (radionuclide imaging)</term>
<term>Delusion</term>
<term>Delusions (psychology)</term>
<term>Delusions (radionuclide imaging)</term>
<term>Dopamine</term>
<term>Dopamine (metabolism)</term>
<term>Dopamine Plasma Membrane Transport Proteins (metabolism)</term>
<term>Female</term>
<term>Hallucination</term>
<term>Hallucinations (psychology)</term>
<term>Hallucinations (radionuclide imaging)</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Lewy Body Disease (metabolism)</term>
<term>Lewy Body Disease (psychology)</term>
<term>Lewy Body Disease (radionuclide imaging)</term>
<term>Lewy body dementia</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neostriatum (metabolism)</term>
<term>Neostriatum (radionuclide imaging)</term>
<term>Nervous system diseases</term>
<term>Neuropsychological Tests</term>
<term>Nucleus Accumbens (metabolism)</term>
<term>Nucleus Accumbens (radionuclide imaging)</term>
<term>Parkinson Disease (psychology)</term>
<term>Parkinson Disease (radionuclide imaging)</term>
<term>Parkinsonism</term>
<term>Photon</term>
<term>Psychiatric Status Rating Scales</term>
<term>Putamen (metabolism)</term>
<term>Putamen (radionuclide imaging)</term>
<term>Radiopharmaceuticals (diagnostic use)</term>
<term>Single photon emission tomography</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
<term>Tropanes (diagnostic use)</term>
<term>delusion</term>
<term>dementia with Lewy bodies</term>
<term>hallucination</term>
<term>parkinsonism</term>
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<term>Tropanes</term>
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<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Dopamine</term>
<term>Dopamine Plasma Membrane Transport Proteins</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Caudate Nucleus</term>
<term>Lewy Body Disease</term>
<term>Neostriatum</term>
<term>Nucleus Accumbens</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Delusions</term>
<term>Hallucinations</term>
<term>Lewy Body Disease</term>
<term>Parkinson Disease</term>
</keywords>
<keywords scheme="MESH" qualifier="radionuclide imaging" xml:lang="en"><term>Caudate Nucleus</term>
<term>Delusions</term>
<term>Hallucinations</term>
<term>Lewy Body Disease</term>
<term>Neostriatum</term>
<term>Nucleus Accumbens</term>
<term>Parkinson Disease</term>
<term>Putamen</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Female</term>
<term>Humans</term>
<term>Image Processing, Computer-Assisted</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neuropsychological Tests</term>
<term>Psychiatric Status Rating Scales</term>
<term>Tomography, Emission-Computed, Single-Photon</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Dopamine</term>
<term>Délire</term>
<term>Démence à corps de Lewy</term>
<term>Hallucination</term>
<term>Parkinsonisme</term>
<term>Pathologie du système nerveux</term>
<term>Photon</term>
<term>Tomoscintigraphie émission monophotonique</term>
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<front><div type="abstract" xml:lang="en">Neuropsychiatric symptoms are frequent in dementia with Lewy bodies (DLB). Dopamine transporter (DAT) imaging with 123I‐labeled ligand N‐δ‐(fluoropropyl)‐2β‐carbomethoxy‐3β‐(4‐iodophenyl)tropene (123I‐FP‐CIT), which reliably measures midbrain dopaminergic dysfunction, has provided important evidence on the neurobiological substrate of some of these symptoms including apathy and depression. However, little is known on DAT levels and other distressing symptoms such as delusions and hallucinations. Therefore, 123I‐FP‐CIT imaging was performed in 18 well‐characterized patients with DLB, and striatal DAT levels were correlated with the frequency/severity ratings of several neuropsychiatric symptoms. A wide range of neuropsychiatric symptoms could be observed in the sample. Significant correlations were observed between decreased striatal DAT levels and visual hallucinations. Although there were no correlations between striatal DAT levels and other neuropsychiatric symptoms, when considering the putamen and the caudate nucleus separately, delusions, depression, and apathy were inversely correlated to decreased caudate DAT levels. Theseresults provide intriguing evidence on the involvement of the mesocortical dopaminergic pathways in neuropsychiatric symptoms in DLB. © 2009 Movement Disorder Society</div>
</front>
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